Uploading 200 to 300MB files on the front end using Safe Cracker or equivalent FTP method

Howdy. Got a project where I need the ability to allow users (on the front end) to upload very large files (200 to 300MB). I found Remote File Browser which seemed perfect (but no Safe Cracker support). I have also found Simple S3 Uploader (waiting for S3 Account to become active) and have not tested it yet.

Can anyone offer a solution?

I would love something that works within EE but am also happy with something I can just throw into a template and sits outside of everything.

Also open to suggestions that may help me to keep my session alive etc, coz I got something working with Mega Upload, but my upload always stopped at 10.9MB.

A few questions have been asked here, any help greatly appreciated.

Cheers. =)