Oops, I saw that Mark also answered this one simultaniously
I use Adobe illustrator to develop the design, and I never use the slice tool; it’s terrible.
If you want just a simple page but don’t want to know anything about HTML, I suggest you use the WYSYWIG functions of Dreamweaver. I started with that and gradually switched from the design panel to the code panel. But this only works if you build a site without EE. If you will never use more than ten pages and only change them every now and then, you don’t need to use EE.
If you need a more complex site where other people can contribute than you’ll need something like EE. But you won’t get it done without some decend HTML knowledge.
There are two sides to this story. Once a system like EE is build anyone can contribute content without having to know how it works and that is the beauty of it. Building such a system can however not be done with zero knowledge. Setup is pretty straightforward, but adjusting is a thing for developers. I think you got these two roles mixed up?
There are websites that you can setup with zero knowledge, hosted services like Blogger and VOX do this, but then you won’t be able to make your own design. Wordpress has a huge amount of templates to choose from, people use this with limited knowledge. If you make the website for yourself, you could try it. I would be hesitant to use it for a client, because what can you do if the system fails and you don’t really understand how it works?