I have been keeping the exp:entries open for most of a page because I figured it would be better performance than opening it on different sections of the page and closing it.
But I have seen some samples that would open and close the exp:entries for example to display the side bar, then one for the content, and sometimes even again for another section of the template. I have been opening it when it is first needed, and if there are multiple areas that require it (sidebar, left content, and maybe somewhere else on the page) keep it open, then close it when it is last required.